{"id":148263,"date":"2023-09-21T11:11:09","date_gmt":"2023-09-21T14:11:09","guid":{"rendered":"https:\/\/www.daniel-ip.com\/?p=148263"},"modified":"2023-09-21T11:18:09","modified_gmt":"2023-09-21T14:18:09","slug":"insights-for-patent-protection-of-car-t-cells-related-technologies-in-brazil","status":"publish","type":"post","link":"https:\/\/www.daniel-ip.com\/en\/articles\/insights-for-patent-protection-of-car-t-cells-related-technologies-in-brazil\/","title":{"rendered":"Insights for patent protection of car-t cells-related technologies in Brazil"},"content":{"rendered":"

Chimeric antigen receptor (CAR) T-cell therapy is a personalised cancer treatment that is gaining greater visibility and enthusiasm as research advances and success in treating patients is confirmed.
\nIn a simplified way, the production of CAR-T cells works as follows:<\/p>\n

    \n
  1. The patient’s blood is collected and processed to separate the patient’s T cells, which are the most important cells in the human defence system<\/li>\n
  2. The patient’s T-cells are genetically engineered to insert the Chimeric Antigen Receptor (CAR) into the cells<\/li>\n
  3. The CAR-T cells are multiplied according to the patient\u2019s need; and<\/li>\n
  4. The CAR-T cells are infused back into patient\u2019s body.<\/li>\n<\/ol>\n

    CAR-T cell therapy brings hope to patients who no longer respond to conventional cancer treatments, where T-cells lose the ability to see and attack cancer cells, as they regain this property and may recognise and kill cancer cells.<\/p>\n

    Approved drugs and ongoing clinical trials<\/strong>
    \nCurrently, there are seven FDA-approved treatments using CAR-T cells[1]<\/span><\/strong><\/sup>, namely: Axicabtagene ciloleucel (Yescarta\u2122); Brexucabtagene autoleucel (Tecartus\u00ae); Ciltacabtagene autoleucel (Carvykti\u2122); Idecabtagene vicleucel (Abecma\u00ae); Lisocabtagene maraleucel (Breyanzi\u00ae); Tisagenlecleucel (Kymriah\u00ae); and Tocilizumab (Actemra\u00ae). In parallel, several clinical trials are ongoing in the world.<\/p>\n

    In Brazil, the Cell Therapy Center of Funda\u00e7\u00e3o Hemocentro de Ribeir\u00e3o Preto is the national pioneer in the production of CAR-T cells for the treatment of cancer patients. Currently, in partnership with the Federal University of S\u00e3o Paulo and the Butantan Institute, clinical trials are ongoing and have shown promising results: so far, 14 patients have been treated with this therapy and all of them had remission of at least 60% of the tumours[2]<\/sup><\/strong><\/span>.<\/p>\n

    Because it is a personalised cell therapy that uses extremely complex technology, the costs of the therapy are very high, which makes it difficult for the population to access it. A great differentiator in Brazil is the fact that this treatment, through the clinical trials mentioned above, is funded by the federal government through the Unified Health System (SUS).<\/p>\n

    The development of the CAR-T cells technology x Intellectual Property<\/strong>
    \nA global vision of how this technology is developing in a patent scenario shows that the United States, China and Europe are the territories where the most patents related to CAR-T cells are filed, indicating that these are the places where research\/clinical tests are being developed more actively.<\/p>\n

    CAR-T cell therapy is a recent and promising technology, which is evidenced by the considerable increase in the number of patents filed from 2018 onwards.<\/p>\n

    Going deeper in the patent scenario, results from searches in specific patent databases show that almost all (96%) patents related to T-CAR cells refer to the treatment of cancer, with few occurrences within the microbial\/fungal\/biofilm, as well as pet\/animal\/livestock technical fields.<\/p>\n

    Additionally, the Applicants who filed more patent applications related to this technology are Juno Therapeutics INC and KITE PHARMA INC. Other companies seem to be developing technologies related to the CAR-T cells, such as HANGZHOU DAC BIOTECH and CRISPR Therapeutics AG.<\/p>\n

    Looking at the Brazilian scenario, we identified in the Brazilian PTO\u2019s database a little more than 30 patent applications whose title or summary includes the expression “CAR-T Cells”, with most of these filings being from 2019 onwards. Brazil will certainly follow the exponential growth in the area, reflecting not only domestic investment but also the commercial interests of foreign clients.<\/p>\n

    Although therapies based on CAR-T cells are already a reality, much research and many improvements are still needed in relation to the technology used, to reduce risks and side effects during their use. The several ongoing clinical trials will certainly contribute to an even more effective and accessible therapy, and it is expected that the inventions associated with these improvements will continue to grow in the coming years, reflecting in a greater number of patent applications directed to this technological area.<\/p>\n

    FICPI’s view and involvement<\/strong>
    \nFICPI uniquely combines education and advocacy on topics around patents and trade marks, with a focus on developing the professional excellence of its individual members. FICPI Forums, Congress, committees and meetings are opportunities to gather insights from the international IP attorney community on any issue, whether it be practice-related or topics of patent and trade mark law.<\/p>\n

    Next steps<\/strong>
    \n\u2022 Search for FICPI members in Brazil by navigating to the FICPI member directory<\/a> and searching by country.
    \n\u2022 Events such as     FICPI\u2019s 2023 Open Forum<\/a> (4-7 October, London) offer the opportunity to attend technical sessions, and to meet and further discussions in congenial surroundings.<\/p>\n

    [1]<\/span><\/strong><\/sup>https:\/\/www.lls.org\/treatment\/types-treatment\/immunotherapy\/chimeric-antigen-receptor-car-t-cell-therapy#FDA%20Approved%20Treatments<\/a>
    \n[2]<\/strong><\/span><\/sup>    https:\/\/www.hemocentro.fmrp.usp.br\/terapia-experimental-com-celulas-car-t-alcanca-remissao-em-paciente-com-cancer-ha-13-anos\/<\/a><\/p>\n

     <\/p>\n

    Article published on FICPI<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Chimeric antigen receptor (CAR) T-cell therapy is a personalised cancer treatment that is gaining greater visibility and enthusiasm as research advances and success in treating patients is confirmed. In a simplified way, the production of CAR-T cells works as follows: The patient’s blood is collected and processed to separate the patient’s T cells, which are […]<\/p>\n","protected":false},"author":107,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[11,373],"tags":[],"ppma_author":[148,988,174],"acf":[],"yoast_head":"\nInsights for patent protection of car-t cells-related technologies in Brazil - DANIEL LAW<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.daniel-ip.com\/en\/articles\/insights-for-patent-protection-of-car-t-cells-related-technologies-in-brazil\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Insights for patent protection of car-t cells-related technologies in Brazil - DANIEL LAW\" \/>\n<meta property=\"og:description\" content=\"Chimeric antigen receptor (CAR) T-cell therapy is a personalised cancer treatment that is gaining greater visibility and enthusiasm as research advances and success in treating patients is confirmed. 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Melbourne, Australia 2016 \u2013 Professional Training in Industrial Property (ABAPI) \u2013 Rio de Janeiro, Brazil 2017 - Chemistry Bachelor\u2019s Degree from the Federal University of Rio de Janeiro (UFRJ) \u2013 Rio de Janeiro, Brazil. 2018 - JPO \/ IPR Training Course for IP Protection Lawyers in Tokyo \u2013 Tokyo, Japan 2019 - Training Course on European and German Patent Law \u2013 Munich, Germany","affiliations-commissions-and-collegiate":"","afiliacoes-comissoes-e-colegiados":"","areas-de-atuacao":"","formacao":"2013 \u2013 2014 \u2013 Aluno de Interc\u00e2mbio na Monash University - Melbourne, Austr\u00e1lia2016 - Treinamento Profissional em Propriedade Industrial (ABAPI) \u2013 Rio de Janeiro, Brasil2017 \u2013 Bacharel em Qu\u00edmica pela Universidade Federal do Rio de Janeiro (UFRJ) \u2013 Rio de Janeiro, Brasil2018 - JPO\/IPR Training Course for IP Protection Lawyers \u2013 T\u00f3quio, Jap\u00e3o2019 - Training Course on European and German Patent Law \u2013 Munique, Alemanha","position":"","first_name":"Luis","description":""},{"term_id":174,"user_id":133,"is_guest":0,"slug":"samantha-salim","display_name":"Samantha Salim","avatar_url":{"url":"https:\/\/www.daniel-ip.com\/wp-content\/uploads\/2021\/09\/Samantha-Salim.png","url2x":"https:\/\/www.daniel-ip.com\/wp-content\/uploads\/2021\/09\/Samantha-Salim.png"},"pratice_areas":"","linkedin":"https:\/\/www.linkedin.com\/in\/samantha-salim-55771938\/","user_url":"","last_name":"Salim","cargo":"Especialista de Patentes","education":"Graduated in Intellectual Property Law from the Pontifical Catholic University of Rio de Janeiro \u2013 PUC-Rio, 2016, with the dissertation \u201cSelection invention: a comparative study encompassing concepts, patentability criteria and case law on this theme\u201d;\r\nDegree in Chemical Engineering from the Fluminense Federal University (UFF) in 2012, with the dissertation \u201cTrend analysis to improve delayed coking units\u201d.","affiliations-commissions-and-collegiate":"","afiliacoes-comissoes-e-colegiados":"","areas-de-atuacao":"","formacao":"P\u00f3s-gradua\u00e7\u00e3o em Direito da Propriedade Intelectual pela Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro (PUC\/RJ), 2016, com trabalho de conclus\u00e3o intitulado \u201cInven\u00e7\u00e3o de sele\u00e7\u00e3o: um estudo comparativo envolvendo conceitos, crit\u00e9rios de patenteabilidade e jurisprud\u00eancias sobre o tema\u201d;\r\nGradua\u00e7\u00e3o em Engenharia Qu\u00edmica pela Universidade Federal Fluminense \u2013 UFF, no ano de 2012, com trabalho de conclus\u00e3o intitulado \u201cEstudo de tend\u00eancias para aprimoramento das unidades de coqueamento retardado\u201d.","position":"","first_name":"Samantha","description":""}],"_links":{"self":[{"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/posts\/148263"}],"collection":[{"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/users\/107"}],"replies":[{"embeddable":true,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/comments?post=148263"}],"version-history":[{"count":2,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/posts\/148263\/revisions"}],"predecessor-version":[{"id":148269,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/posts\/148263\/revisions\/148269"}],"wp:attachment":[{"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/media?parent=148263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/categories?post=148263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/tags?post=148263"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.daniel-ip.com\/en\/wp-json\/wp\/v2\/ppma_author?post=148263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}